Archive for the ‘Review’ Category

USMLE Step 1 Exam

Monday, August 31st, 2009

The USMLE Step 1 exam covers the contents of the first 2 years of medical school (pre-clinical sciences). The subjects include:-

  • Gross Anatomy
  • Pathology
  • Neuroanatomy
  • Pharmacology
  • Histology
  • Microbiology
  • Embryology
  • Immunology
  • Physiology
  • Behavioral Science
  • Biochemistry
  • Biostatistics
  • Genetics

This may appear mind boggling at first sight but actually many are subtopics in the major subjects. The reason for this classification is that many books are written for these specific topics separately.

Time to prepare for the exam depends from person to person. Generally IMG’s prepare for about 3-6 months for the exam.


Exam Registration

The application for the USMLE exams may be submitted online or via regular mail as described in the introduction.

Once registered the applicant receives the Orange permit card which is used to register for the exam either by phone or online (Prometric centers). Along with the permit the examinee will also receive a CD containing 3 blocks of sample questions and the software tutorial.


Exam Design

Step 1 is a one day exam. The total exam duration is 8 hours. The exam consists of 7 blocks of 50 questions each which have to be finished in 1 hour. So the actual exam time is 7 hours. There is a 15 minutes tutorial to let applicants get familiar with the software and 45 minutes of break time. So the total duration of the exam totals to 8 hours.

Applicants are allowed to take a break after finishing a block but not during a block. The applicant may take as many or as few breaks as he likes as long as he does not leave the exam room in the midst of a block. Also note that once a block has started, it has to be finished before the applicant may take a break. If a block is closed without completing it there is no way in which it may be opened again.

If the tutorial is finished earlier then the remaining time gets added to the break time. Similarly if a block is finished earlier then also the time gets added to the break time. This extra time cannot be used to extend the time of some other block.

Each block will contain a mix of questions from the various subjects. No particular subject is more important than others. To put it crudely every subject is as important as the thickness of the book used for exam preparation and therefore every book should be read thoroughly.


Questions on the exam

Questions are multiple choice type and may carry between 3 to 10 choices per question. Most of the questions are framed in a clinical scenario. All questions carry equal weightage and there is no negative marking.

A point to note is that not all questions on the actual exam will be scored. They are there for experimental purposes to analyze if they are suitable to be scored in future exams (e.g. some questions may be too tough, too easy or wrongly framed). According to the USMLE website anywhere between 10-20% of the questions on the exam may not be included in the final score. So if you are talking a long time on a particular question, you may want to select your favorite letter and move on.


Result Reporting

The results of the exam are generally reported between 4-6 weeks after taking the exam. The results of the exam are reported in a 2 digit and a 3 digit score.

Introduction to USMLE

Monday, August 31st, 2009

The United States Medical Licensing Examination (USMLE) is a series of examinations which medical undergraduate, postgraduate and professionals need to take in order to enter into a residency in the United States.

There a total of 4 exams:-

Step 1 – Covers pre-clinical subjects (e.g. Anatomy, Physiology etc)

Step 2 CK (Clinical Knowledge) – Covers clinical subjects (e.g. Medicine, Surgery etc) with emphasis on diagnosis

Step 2 CS (Clinical Skills) – Clinical case encounters with simulated patients

Step 3 – Clinical subjects with more emphasis on actual management (Not required to enter into residency)


Eligibility Criteria and Application

The USMLE exams can be taken anytime after completion of at least 2 years of medical school or the basic science medical component. These exams may be taken in any order which the applicant chooses. For e.g. Step 2 CS may be taken first followed by Step 1 and then Step 2 CK.

Please note that that there is no requirement that an applicant needs to complete his/her medical school before taking the exam. Essentially this means that anyone can take the Step 2 CS exam after passing the basic science years (The ECFMG website recommends but does not enforce that the applicant should have completed their core clinical rotations before taking the exam).

All international medical graduates (IMG) need to apply for these exams through the ECFMG (Educational Commission for Foreign Medical Graduates). The ECFMG provides both an online and paper based application form. The online form is generally processed much faster than the paper based version. Also one should note that even the online version of the form requires you to print the “Certification of Identification form” (Form 186) after completion of the online part and send it by regular mail.

When an applicant registers for an exam, they are required to select a 3 month period during which they will take the exam. After receiving the registration (orange card), the applicant needs to contact Thomson Prometric by either phone or register online to set up a date to take the exam. The exam can be taken throughout the year except on Saturday and Sunday.


ECFMG Certificate

The ECFMG certificate is awarded after the successful completion of Step 1 and 2 (CK and CS). This certificate is necessary to participate in the National Residency Matching Program (NRMP) or the Match and therefore to enter into a residency program.


Costs Involved

The whole process to get into a residency in the United States is an expensive affair. Lets make some rough calculations -

USMLE Step 1 $700
USMLE Step 2CK $700
USMLE Step 2CS $1200
Residency Applications (Approx 50 programs) $1000
Traveling for interviews (Approx 10-12) $4000
Total $9100

So the whole process for the IMG approximately costs between $8000 – $12000.

Review of the Cardiac Cycle

Friday, August 14th, 2009

This excellent video provides a quick review of the cardiac cycle:


Via Dr. Wes

Men’s health videos

Friday, July 10th, 2009

Videos on Men’s Health from British Medical Journal. They are geared more towards improving the British National Health System on raising awareness, case finding and treating men’s health issues.

“Health professionals need to talk to men about their problems in the sort of language they use and should move primary care into the workplace to make it easier for men to access health services, a debate held by the Mens Health Forum heard.

Men currently use healthcare services far less effectively than women, and a recent Cancer Research UK survey found that men are almost 40% more likely than women to die from cancer (http://info.cancerresearchuk.org/cancer stats).”




Review: Muscle pain due to statins

Friday, July 3rd, 2009

Statins are probably the best medications to reduce cholesterol level and also have associated anti-inflammatory activities. Both these properties lead to a marked decrease in atherosclerosis and related diseases.

Muscle pain is quite common in people (up to 10%) who take one of the several statins for lowering their cholesterol levels. However, there is no strict consensus on how to define, diagnose and manage such muscle pains.

The Annals of Internal Medicine recently published an excellent review on “Statin related myopathy.” Here is a brief summary of the article.

Definition:

There is no consensus definition. Each group (ACC/AHA, FDA etc) have their own definitions. For most clinical purposes the following definitions should be adequate:

Myopathy: Muscle disease with creatine kinase > 10 time upper limit

Rhabdomyolysis: Creatine kinase elevation with end organ damage

Pathophysiology:

Incompletely understood. Proposed mechanisms include:

  1. Decreased cholesterol content of skeletal myocyte membrane leading to instabilty
  2. Depletion of isoprenoids and/or coenzyme Q10
  3. Mitochondrial dysfunction

Risk factors for developing myopathy:

  • Advanced age
  • Smaller body size
  • Multi-system diseases (including hypothyroidism)
  • Alcoholism
  • Major surgery, excess physical activity
  • History of myopathy while on other lipid lowering agent
  • Family history
  • Higher doses of statin
  • Interaction with other drugs leading to increased bio-availability of statins

Clinical Features:

Major site of muscle pain were in the thighs, calves or it was generalized. Pain was described as heaviness, stiffness or cramping and sometimes was associated with exertion. Physical exertion was a common trigger of myalgia. Tendon pain may also be present.

Management:

  • Check creatine kinase (CK) levels in high risk patients
  • If CK levels > 10 times upper limit, stop statin
  • Re-initiate statin with a lower dose once CK levels return to normal
  • Try switching to fluvastain (better tolerated) or rosuvastatin (less interaction with other medications)
  • Atorvastatin and Rosuvastatin have long half life and can be administered on alternate days
  • Trial of other lipid lowering agents (e.g. Bile acid binders, ezetimibe, niacin etc)
  • Co-enzyme Q10 supplementation may tried. No clear benefit but is very safe.