Posts Tagged ‘Cancer’

Smoking and Lung Cancer Genes

Sunday, August 2nd, 2009

Video from the Nature Publishing Group on the risks of smoking coupled with the genetics of its addiction and genes that lead to cancer development.

“Some of the strongest evidence that lung cancer risk variants are common in the general population appears in Nature and Nature Genetics, although the three papers differ on whether the association is direct or mediated through nicotine dependence. Watch the research being discussed here. Stephen Chanock, David Hunter and Kari Stefansson discuss how your genes can affect your addiction to nicotine and your cancer risk from smoking.”

[Link to Video]


New way to harvest bone marrow for stem cell transplant

Saturday, July 18th, 2009

Bone marrow is the seat of stem cells which give rise to the cells that circulate in blood. These cells are:

Red cells (erythrocyte) – carry oxygen

White cells (leukocyte) – fight infections

Platelets (thrombocyte) – help with blood clotting

Blood Cell Lineage


Illu_blood_cell_lineage.jpg

Image source: Wikipedia

There are a number of diseases in which the bone marrow stem cells may die, be replaced by fibrous tissue or by cancer which then leads to decreased blood cells. This defect will then lead to fatigue, tiredness (due to decreased red cells), repeated infections (due to decreased white cells) and easy bleeding (due to decreased platelets).

The technique of harvesting stem cells from a donor bone marrow for transplant to a recipient whose marrow is not functioning is a life saving procedure. However, the technique for harvesting these cells is very old, painful and has a fair share of complications.

In this TED talk, Daniel Kraft demonstrates a new device which aims to make the whole process of bone marrow harvesting for stem cell transplant safer and simpler (Link to Video).


More information on Stem Cell Transplantation – Mayo Clinic

The story of how smoking was linked to cancer and other diseases

Tuesday, July 7th, 2009

Watch this amazing video from the British Medical Journal archives:

“Richard Doll was a luminary of clinical research whose case control study, published in the BMJ in 1950, first identified smoking as an important cause of cancer and other diseases.

He carried his research out on doctors in the UK who smoked, and tracked their mortality over the course of 50 years. The latest paper being published in the BMJ in 2004.”


Smoking now is linked to a large number of disease and it affects virtually every organ system of the body.

Information on how to quit smoking from Medline Plus: Quitting Smoking

Obesity linked to pancreatic cancer

Wednesday, June 24th, 2009

Pancreatic cancer is the fourth leading cause of death in United States. Once diagnosed, patients have a very poor prognosis with median survival between 3 to 6 months.

8Dudenumandpancreas.jpg

A new study published in the Journal of American Medical Association has found a link between being obese in early adulthood and the risk of developing pancreatic cancer.

Individuals who were overweight (BMI of 25-29.9) from the ages of 14 to 39 years or obese (BMI > 30) from the ages of 20 to 49 years were at about twice the risk of developing pancreatic cancer (OR 1.67 & 2.58 respectively), independent of diabetes status. Also obesity at older age was associated with lower overall survival in patients with this malignancy.

The main drawback of the study is that this is a case control study, therefore the 2 factors studied (viz. pancreatic cancer and obesity) could occur together but not be causally related (although the authors did do adjust for most other risk factors of pancreatic cancer).

Reference: JAMA – Body Mass Index and Risk, Age of Onset, and Survival in Patients With Pancreatic Cancer

Links for more information on pancreatic cancer: Mayo Clinic, National Cancer Institute

Update (6/29/2009): YouTube Video from JAMA


Early Diagnosis of Mesothelioma Critical for Effective Treatment

Monday, June 1st, 2009

Guest Post:

This is a guest post by Richard Moyle from the Mesothelioma Cancer Center at Asbestos.com. The Mesothelioma Cancer Center is committed to providing the latest, up-to-date information to their visitors in the hopes of spreading awareness about the dangers of asbestos cancer.

Mesothelioma is the name given to a rare and extremely aggressive cancer thatís only known cause is exposure to asbestos. Asbestos was used throughout the 20th century for insulation, brake lining, flooring and piping. The most common type of mesothelioma occurs in the lining of the lungs (pleura) but has also been diagnosed in the linings of the stomach (peritoneum) and heart (pericardium).

This type of cancer is most effectively treated when diagnosed in its earliest stages. Regrettably, mesothelioma symptoms take anywhere from 25 to 50 years after initial asbestos exposure to begin to show. By the time a mesothelioma diagnosis is usually made, the cancer is already in advanced stages and treatment options are limited and less effective.

As stated before, asbestos was used extensively in a number of military and industrial applications. The majority of mesothelioma cases are a result of occupational asbestos exposure. Firefighters, military veterans, electricians and auto mechanics are among those most at-risk for developing an asbestos related illness.

Homes built before 1980 may also contain asbestos insulation. This is not a problem so long as the asbestos has not been disturbed or damaged. Asbestos is harmless if left alone. However, once the material is damaged or deteriorated, microscopic asbestos fibers are released into the air where they can then be easily inhaled or ingested. If you live in an older home, make sure you consult a professional home inspector to check the house for asbestos before making any major renovations.