Posts Tagged ‘Heart Attack’

Eat veggies to lower your blood pressure

Monday, July 20th, 2009

I am a vegetarian.

Often people are surprised and they ask me – “How do you get your proteins (i.e. without eating meat)?”

My answer – “Vegetables also contain proteins.”

451px-Arcimboldo_Vegetables.jpg
Image Source: Wikipedia

Now a new study published in Circulation compared the blood pressure between individuals who ate vegetable protein (specifically glutamic acid along with 4 other amino acids which are relatively higher in vegetable than animal protein) with people who ate non-vegetable protein (read animal meat).

They found a difference of about -2.7/-2.0 mm Hg in blood pressure in people eating more vegetables. Although that may sound small, individual results may be different (and maybe higher for you).

Reference: Glutamic Acid, the Main Dietary Amino Acid, and Blood Pressure (The INTERMAP Study)

The story of how smoking was linked to cancer and other diseases

Tuesday, July 7th, 2009

Watch this amazing video from the British Medical Journal archives:

“Richard Doll was a luminary of clinical research whose case control study, published in the BMJ in 1950, first identified smoking as an important cause of cancer and other diseases.

He carried his research out on doctors in the UK who smoked, and tracked their mortality over the course of 50 years. The latest paper being published in the BMJ in 2004.”


Smoking now is linked to a large number of disease and it affects virtually every organ system of the body.

Information on how to quit smoking from Medline Plus: Quitting Smoking

Regenerating heart muscles to treat heart failure

Saturday, April 4th, 2009

Traditional medical teaching is that humans die with the heart muscles that they are born with.

Therefore, heart muscles that die when a person has a heart attack, will never regenerate and result in permanent injury akin to formation of scar tissue on skin (although skin does have a limited capacity to regenerate which is why scars do not form after minor skin trauma).

An article published in the Journal, Science seeks to overthrow this concept.

The researchers in their article have demonstrated that there is limited regeneration of heart muscle after birth.

“We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span.”

This finding opens up possibilities of targeting medications to regenerating the heart muscle that is destroyed in a heart attack, thereby preventing a host of complications including heart failure (post myocardial infarction congestive heart failure is the number one cause of heart failure in the United States and is the major contributer of morbidity & mortality after heart attack).

Reference: Science, US News

Does gene analysis provide better risk profiling for heart attack?

Monday, March 30th, 2009

New England Journal of Medicine had published a paper in Aug 2, 2007 titled – “Genomewide association analysis of coronary artery disease.” In this article, the investigators analyzed the entire human genome in an effort to identify genes causing heart attacks and in the process try to predict the risk of heart attack in individuals.

Here is my take on it:

(I have analyzed the article according to a recent series of papers published in JAMA – for more details see here)

(I have removed a few slides from the presentation due to copyright issues)

In spite of having found a genetic association, the risk prediction provided by genetic profiling does not provide enough information to supplant current clinical risk factors (Framingham risk factors and the PROCAM risk score)

Bottom Line: The Home DNA kits that are being marketed provide very little information above and beyond clinical risk profile that physicians already use (atleast for now!)

Angioplasty and Bypass Surgery education videos

Thursday, November 13th, 2008

Animated video explaining how coronary angioplasty with stent insertion is performed. Also called percutaneous coronary intervention (PCI), it is the procedure of choice for most cases of heart attack.

Coronary artery bypass grafting is performed for severe disease as in involvement of all 3 coronary vessels or left main coronary artery.